Admin

Acute decompensated heart failure is a congestion syndrome until proven otherwise. The practical inpatient framework is: assess perfusion and oxygenation, identify the precipitant, aggressively decongest, protect/optimize GDMT, and discharge only after clinical stability with a clear maintenance diuretic and follow-up plan. Core framework 1. Stabilize Assess airway, oxygenation, BP, perfusion, mental status NIV for pulmonary … Read more

Overview EKG

Basal Insulin Fc (BIF) vs Degludec in Type 1 Diabetes Patients Using Multiple Daily Injections Study design: Phase 2, randomized, parallel, open-label study Population: 265 patients with type 1 diabetes (T1D) using multiple daily injections Interventions Primary outcome: HbA1c change from baseline to week 26 Secondary/ Safety outcomes Safety Outcomes BIF once weekly HbA1c change … Read more

Is treat-to-target LDL-C strategy noninferior to high-intensity statin therapy for long-term clinical outcomes in patients with coronary artery disease? Study design: Randomized, multicenter, noninferiority trial Population Interventions Primary outcome: 3-year composite of death, myocardial infarction, stroke, or coronary revascularization Secondary outcomes Safety outcomes or Adverse Events Safety Outcomes Treat-to-Target Group (%) High-Intensity Statin Group (%) … Read more

How does the diagnostic accuracy of chest ultrasonography (CUS) compare to chest X-ray (CXR) for detecting pneumothorax in trauma patients in the emergency department (ED)? Study design: Systematic review and meta-analysis of 13 prospective, paired comparative accuracy studies Population Interventions Primary outcome: Sensitivity and specificity of CUS and CXR for pneumothorax detection Conclusion The diagnostic … Read more

Does torsemide reduce all-cause mortality compared with furosemide in patients with heart failure following hospitalization? Study design: Open-label, pragmatic randomized trial Population Interventions Primary outcome: All-cause mortality in a time-to-event analysis Conclusion Among patients discharged after hospitalization for heart failure, torsemide compared with furosemide did not result in a significant difference in all-cause mortality over … Read more

Efficacy and safety of tirzepatide in people with obesity Study design: Phase 3 double-blind, randomized, controlled trial Population Interventions Primary outcome: Percentage change in weight from baseline and a weight reduction of 5% or more Safety outcomes or Adverse Events Adverse events in 78.9% to 81.8% of participants treated with tirzepatide, compared to 72.0% in … Read more